The Chan Zuckerberg Biohub San Francisco (CZ Biohub SF) (https://www.czbiohub.org/sf/) is an independent nonprofit research institute that brings together three powerhouse universities - Stanford, UC Berkeley, and UC San Francisco - into a single collaborative technology and discovery engine. CZ Biohub SF itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to investigate the fundamental mechanisms underlying disease and develop new technologies that will lead to actionable diagnostics and effective therapies. We are guided by our values of scholarly excellence; disruptive innovation; hands-on engineering/hacking/building; partnership and collaboration; open communication and respect; inclusiveness; and opportunity for all.

Our Vision

We pursue large scientific challenges that cannot be pursued in conventional environments
We enable individual investigators to pursue their riskiest and most innovative ideas
The technologies developed at CZ Biohub San Francisco facilitate research by scientists and clinicians at our home institutions and beyond

Diversity of thought, ideas, and perspectives are at the heart of CZ Biohub Network and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.

The Opportunity

Dr. Loic A. Royer leads an interdisciplinary team of computer scientists, optical engineers, and biologists with a shared vision: mapping the emergence of cell types and states during embryonic development. This ambitious goal, exemplified by their recent Multimodal Atlas of Vertebrate Development (Lange et al.), drives the Royer Group to develop cutting-edge technologies. They combine state-of-the-art light-sheet fluorescence microscopy for live, volumetric, and multi-color imaging of zebrafish embryos with advanced image processing and analysis algorithms. This approach enables cell tracking in whole embryos with unprecedented precision and scale (Bragantini et al.). The project's success hinges on seamless collaboration across diverse fields, including transgenic line development, genomics, and more...

We are seeking a Scientist (PhD-level) who will contribute to building a 'Virtual Zebrafish Embryo' by leveraging these cutting-edge technologies. The successful candidate will be instrumental in advancing our understanding of how embryos develop into fully formed organisms by asking fundamental questions and driving interdisciplinary research. As a key member of our team, you will have the opportunity to work at the frontier of developmental biology, advanced microscopy, single-cell genomics, and computational methods. You will contribute to expanding the Zebrahub platform and play a pivotal role in our mission to create a comprehensive multimodal atlas of cellular behavior in a developing vertebrate organism.

You will report directly to Loic A. Royer, Director of Imaging AI and Senior Group Leader of Quantitative Cell Science at CZ Biohub, San Francisco.

What You'll Do

Design and execution of experiments using advanced light-sheet microscopy, single-cell genomics, and genetic manipulation
Develop innovative transgenic lines using the latest genome manipulation technologies and protocols to facilitate imaging
Collaborate with computational biologists and computer vision and AI experts on applying novel computational methods to analyze and interpret large-scale imaging and multi-omics datasets
Collaborate closely with genomics, bioengineering, and data science platforms to advance the virtual embryo project
Contribute to enhancing and disseminating your work and the broader Zebrahub resource, making your findings accessible to the global scientific community
Publish high-impact papers and present your work at premier international conferences

What You'll Bring

Essential –

Ph.D. in Cell Biology, Developmental Biology, Computational Biology, or a related discipline

>5 years of experience in Developmental Biology

>4 years of experience in advanced microscopy techniques

>3 years of experience with transgenic line development, particularly the latest genetic manipulation technologies like CRISPR

>2 years of experience with single-cell genomics protocols and data analysis pipelines

Solid understanding and knowledge of the variety of fluorophores and their use in live imaging

Computational skills, with experience in analyzing large biological datasets

A proven track record of work on interdisciplinary research projects

Excellent written and oral communication skills

A passion for open science and team-oriented research

Nice to have -

Experience in light-sheet microscopy

Experience with data integration and analysis

Experience with image processing and analysis

Familiarity with zebrafish as a model system

Compensation

The San Francisco, CA base pay range for this role is Scientist I = $100,000.00 - $137,500.00 and Scientist II = $112,000.00 - $154,000.00. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.
What We Provide

Resources to disrupt and innovate at the frontiers of our knowledge of biology and disease

A collegial and collaborative environment consisting of diverse expertise

Access to collaborators, resources and facilities at our three partner universities (Stanford University, UC Berkeley, and UC San Francisco) and at partner organizations in the SF Bay Area and beyond

Competitive compensation and benefits commensurate with the experience

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

Benefits

We offer a robust benefits program that enables the important work Biohubbers do everyday. Our benefits include healthcare coverage, life and disability insurance, commuter subsidies, family planning services with fertility care, childcare stipend, 401(k) match, flexible time off and a generous parental leave policy. In addition, we honor our commitment to career development and our value of scholarly excellence through regular onsite opportunities to learn from the world's leading scientists.

The CZ Biohub Network is an equal opportunity employer committed to diversity of thought, ideas and perspectives. We are committed to cultivating an inclusive organization where all Biohubbers feel inspired and know their work makes an important contribution. Therefore, we provide employment opportunities without regard to age, race, color, ancestry, national origin, religion, disability, sex, gender identity or expression, sexual orientation, or any other protected status in accordance with applicable law.

Pursuant to the California Fair Chance Act, we will consider for employment qualified applicants with arrest and conviction records.

Headhunters and recruitment agencies may not submit resumes/CVs through this website or directly to managers. The CZ Biohub Network does not accept unsolicited headhunter and agency resumes. The CZ Biohub Network will not pay fees to any third-party agency or company that does not have a signed agreement with the CZ Biohub Network.

Scientist, Biological Cartography (Royer Group - Biohub SF)