P-4586 Translational Bioinformatics Staff Scientist

Job Title: Translational Bioinformatics Staff Scientist

Location: Pleasanton, CA or hybrid with regular on-site presence in Pleasanton, CAJob Type: Full-time

About Us: 10x Genomics is at the forefront of genomic and clinical research, providing innovative tools and technologies to analyze complex biological systems at single-cell resolution.

Position Summary:

We are seeking a highly skilled and hands-on Translational Bioinformatics Group Leader to lead a small, dynamic team dedicated to advancing the analysis of human genomic data in translational research. The ideal candidate will possess deep expertise in next-generation sequencing (NGS), single-cell genomics, and high-dimensional data analysis, integrating multi-omic datasets to extract meaningful biological insights with clinical relevance.

This role requires an exceptional combination of statistical rigor, computational proficiency, and biological acumen, ensuring the highest standards of data quality, statistical significance, and reproducibility. The successful candidate will work closely with laboratory scientists, clinicians, and external collaborators, translating complex genomic data into actionable insights that impact human health.

Key Responsibilities:

• Lead and participate in all aspects of genomic data analysis for single cell and spatial genomics, from raw data to clinically relevant insights.
• Design and implement rigorous statistical frameworks to account for batch effects, confounding variables, and high-dimensional data complexities.
• Develop and apply computational pipelines for single-cell NGS and spatial genomics data analysis.
• Integrate multi-omics data (e.g., transcriptomics, proteomics) to generate novel biological insights.
• Collaborate closely with lab scientists and clinicians to design studies, interpret results, and validate findings.
• Stay at the forefront of bioinformatics methodologies and best practices, ensuring state-of-the-art approaches in genomic data analysis.
• Publish in high-impact journals and present findings at top-tier scientific conferences.
• Provide mentorship and hands on leadership to a small team of bioinformaticians and computational biologists.
• Interface with external collaborators and stakeholders to drive research projects forward.

Qualifications & Requirements:

• Ph.D. in Bioinformatics, Computational Biology, Genomics, or a related field, with a strong track record of impactful research.
• Extensive experience in NGS and single-cell analysis, from raw data processing to interpretation of clinical phenotypes.
• Proficiency in statistical programming languages (R, Python) and bioinformatics tools for genomic data analysis.
• Expertise in handling batch effects, normalization strategies, and high-dimensional data interpretation.
• Demonstrated ability to extract biological meaning from large-scale genomic datasets.
• Strong publication record in high-profile peer-reviewed journals.
• Background in elite institutions, either through education or research training, is highly desirable.
• Proven experience in leading projects and collaborating with experimental scientists and clinicians.
• Excellent communication and leadership skills to effectively drive translational bioinformatics initiatives.

Preferred Skills:

• Experience with cloud computing and high-performance computing (HPC) environments.
• Strong familiarity with machine learning applications in genomic data analysis.
• Knowledge of clinical genomics and biomarker discovery.
• Knowledge of 10x Genomics technologies and tools such as the Cell Ranger pipeline and Loupe Browser.
• Familiarity with community-developed tools for single-cell data analysis

Why Join Us?

This is an exciting opportunity to lead cutting-edge translational bioinformatics research in a collaborative and impactful setting. 10x Genomics is committed to scientific excellence, interdisciplinary collaboration, and translational impact in human health. We offer a competitive compensation package and the opportunity to work on high-impact projects with leading experts in the field.

If you are a driven bioinformatics leader with a passion for rigorous data analysis, biological discovery, and translational impact, we encourage you to apply.

Below is the base pay range for this full-time position.  The actual base pay will depend on several factors unique to each candidate, including one’s skills, qualifications, and experience.  At 10x, base pay is also just one component of the Company’s total compensation package.  This role is also eligible for 10x’s equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. During the hiring process, your 10x recruiter can share more about the Company’s total compensation package.

About 10x Genomics

At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference. 

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.

10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.